This is a brainteaser by S. Ageyev from the November-December 1991 issue of Quantum given in Futility Closet.

“The numbers 1, 2, …, 100 are arranged in a 10 x 10 square table in their natural order (1 in the top left comer, 100 in the bottom right comer). The signs of 50 of these numbers are changed in such a way that exactly half of the numbers in each line and each column get the minus sign. Prove that the sum of all the numbers in the table after this change is zero.”

See Mixed Emotions for solutions.